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A 2019 study found that older adults supplementing high doses of vitamin B12 were at an increased risk of colon cancer

Redundancy of the angiogenic signals The main angiogenic pathway is the VEGF one [59] however it is not the only and, in its complexity, interacts with several other pathways

FDA nonclinical toxicology review (2023-2024) flagged DNA damage in pituitary cells and injection-site necrosis in animal studies, plus immunogenicity and impurity risks from compounded material, alongside GH/IGF-1-axis effects such as fluid retention, joint discomfort, flushing, and headache reported by users

This isn't speculation

However, evidence directly applicable to musculoskeletal clinical outcomes remains limited