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doi: 10.3390/antiox12081646
[DOI] [PMC free article] [PubMed] [Google Scholar] 176.Schmidt EE
55 MontgomeryH.DoymockJ
Y-27,632 is a competitive inhibitor of both Rho-associated protein kinase ROCK1 and ROCK2 (serine-threonine kinases) that competes with ATP in binding the catalytic binding sites of these kinases and thereby interferes with membrane protrusion and vesicle shedding through suppressed activity on LIM kinase and myosin light chain (MLC) 9
This knowledge is useful for designing therapeutic interventions and understanding chemoresistance due to GST polymorphisms
