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Researchers have discovered a potent and selective glutamine transporter inhibitor, V9302, which specifically targets the SLC1A5 and effectively inhibits glutamine uptake [191].SLC1A5 has been reported to be involved in the modulation of the immune microenvironment in multiple types of tumors

CagriSema has the stronger evidence base with completed phase 3 REDEFINE trials showing 20.4% weight loss, and is closer to potential approval

Inhibition of GPX4 activity leads to the accumulation of lipid peroxides, which triggers ferroptosis

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The autoimmune response against stomach cells that produce intrinsic factor causes pernicious anemia while insufficient vitamin intake affects general anemia development