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Structurally, HSP70 proteins contain two main domains: an N-terminal nucleotide-binding domain (NBD) and a C-terminal substrate binding domain (SBD)

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In the present analysis, valine and leucine levels were tended to be higher in the fatigued group irrespective of HD modalities, possibly reflecting delayed muscle metabolism of branched-chain amino acids in fatigued patients due to reduced muscle mass 45