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If universally adopted, this new nomenclature and definition will have a great impact on clinical practice [3,4] , particularly with respect to the diagnosis of patients and endpoints for clinical trials [5]

6.3 Assessment of total antioxidant capacity (TAC) CF pathophysiology involves disrupted cellular equilibrium alongside persistent inflammatory responses that drive progressive tissue deterioration, with particular severity in pulmonary manifestations (OSullivan and Freedman, 2009)

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RecA binds single stranded DNA, eliciting transcriptional changes that can inhibit proper cell division 31

Critical Reviews in Toxicology, 29: 543568