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Diamine oxidase (DAO), which is synthesized by mature enterocytes located in the upper intestinal villi [9], is the main enzyme for histamine degradation [10,11]

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Long-term data from a 52-week clinical study found that escitalopram reduced relapse risk by 2.8 times compared with placebo, with 22% of escitalopram-treated patients relapsing versus 50% on placebo, supporting maintenance treatment after improvement, according to this 52-week social anxiety relapse-prevention study on PubMed