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Preclinical studies have explored GHK-Cu effects in cardiovascular applications, where the peptide demonstrates capacity to reduce atherosclerotic plaque formation in hyperlipidemic mice through anti-inflammatory effects and improved endothelial function

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Using an encyclopedic series of opioid ligands together with multiple measures of ligand-receptor-effector interaction in cell lines, two recent studies correlated agonist efficacy with the ability to induce receptor internalization (McPherson et al., 2010
