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Bernal W, Lee WM, Wendon J, Larsen FS, Williams R

Effects of growth hormone on insulin resistance and atherosclerotic risk factors in obese type 2 diabetic patients with poor glycaemic control

The NHS weight loss plan focuses on sustainable lifestyle modifications, including: Calorie reduction through portion control and healthier food choices Increased physical activity (minimum 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities at least twice weekly) Behavioural strategies and goal-setting Referral to specialist weight management services based on local criteria Referral thresholds for weight management services vary by locality

Irisin and IL-6 reduce pro-inflammatory cytokine expression, limiting chronic inflammation that drives retinal injury (125, 179), whereas BDNF and irisin strengthen endogenous antioxidant defenses to prevent ROS-mediated neuronal damage (180182)