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Stress Biol
In several cancer cell lines, including HT1080 and PANC1, the knockdown of NCOA4 prevents erastin-induced ferritin breakdown, iron buildup, and ferroptosis
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The ideal treatment timing is the early stage of degeneration, when the disc structure is relatively intact (annulus fibrosus not ruptured, endplate not calcified), and functional cells remain
It's the professional standard for a reason
