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Beta-3 Adrenergic Receptor (3-AR) Pathway Activation The primary documented mechanism of AOD-9604 in laboratory research models is activation of the beta-3 adrenergic receptor (3-AR), a G-protein-coupled receptor expressed predominantly in adipose tissue

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The reduced norepinephrine release may be beneficial also in other conditions with sympathetic hyperactivity such as heart failure and myocardial infarction in addition to the sparing effect of 1 -blockers on cardiac work load and energy consumption

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