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The human results were real but modest

Chronic administration of dihydrotestosterone (DHT) and estradiol promotes proinflammatory cytokines within the prostate in rats

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For information about supplements that have been investigated in humans for athletic performance and joint health, see our Reviews of Muscle and Workout Supplements , Collagen Supplements , Nitric Oxide Supplements , and Joint Health Supplements

That means there is no strong human trial data to help answer basic questions: What dose is safe