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Total Hg was used as biomonitoring data since it can give precise information on the total internal exposure of an individual at a given point in time, whereas total hair-mercury was used as a confounder for the effects of methyl-Hg due to fish/seafood consumption 52,53

Statements Author contributions QL and KW conceived and designed the scope of the review

Challenges and limitations Decades of preclinical data now strengthen the claim that 7nAChRs are expected to be effective treatment targets for ASD and other cognitive disorders

Furthermore, we recognize our mouse model is different from the previously studied AKITA mouse model ( M

Physical performance measurably better