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fermentum A51 was found to possess genes implicated in the synthesis of EPS and signaling molecule AI-2, stress response, antioxidant, and antibacterial activities, all of which led to enhanced probiotic activities, including good tolerance to simulated gastrointestinal tract, strong antioxidant and antimicrobial activities

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However, its complex composition, inconsistent efficacy, and geographical limitations in herb cultivation have restricted its widespread acceptance, mainly to countries like China [14]

Generic versions from Chong Kun Dang and Dongkwang Pharm are on the market, but Nexium IV had remained the preferred choice in many institutions due to physician familiarity and its potency, according to hospital specialists