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The preference for the product glycan rather than the substrate raises the possibility that the lectin domain is involved in either prompt product release during the catalytic reaction cycle or the efficient modification of glycoproteins in which 1-4GlcNAc already exists (Fig

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Microscopic crystalline MSU triggers an imbalance in the Th17/Treg ratio within human circulation, subsequently stimulating Th17 proliferation (45)

Other studies suggest that the C99 fragment is highly enriched in subcompartments of the endoplasmic reticulum associated with mitochondria (Pera et al., 2017