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glutathione and metabolism Sex differences in acetaminophen toxicity Biochemical pathway model of glutathione
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doi: 10.1073/pnas.94.11.5531

Manghi P, Filosi M, Zolfo M, Casten LG, Garcia-Valiente A, Mattevi S, et al

The liver depends on intracellular glutathione for detoxification and that requires the compound to actually reach liver cells intact

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it should not be presented as evidence of a proven combination effect
