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Description
Additionally, the melatonin activation of the MT1/MT2 receptors initiates other signaling pathways, such mitogen-activated protein kinases and extracellular-signal-regulated kinase (ERK1/2)
Regulation of the hypoxia-inducible factor-1
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The IGF-1/IGF-1R system has been shown to be an important promoter of tumor growth in various cancers, promoting tumor progression and metastasis by regulating multiple signaling pathways, such as those of PI3K/AKT and MAPK/ERK signaling (78,94)
