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Shultz, P.J

A guide to the development, implementation and evaluation of clinical practice guidelines (PDF)

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The compound demonstrates unique binding properties in experimental models, with particular affinity for select molecular targets

Unlike the APP/PS1 transgenes, which are cDNAs driven by neuron specific Prnp promoter, the R1.40 transgene is the entire human APP genomic sequence with all introns plus tens of kilobases of the 3 and 5 sequences inserted into the mouse genome on a yeast artificial chromosome (35)
