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Microbial proteins are not covered by central tolerance, and their epitopes are highly antigenic, which can bind to host T cell receptor (TCR) and initiate immune response ( In addition, cytokines involved in ICD (such as IFN- and IL-1) and death receptors on the cell surface (such as FAS and TNFR) can also be used as key factors affecting the immune effect ( 2.1.2 ICD adjuvant nature of ICD Adjuvant is another key aspect in ICD process, which determines whether dying cells can effectively recruit and APC, and then start adaptive immune response

[Google Scholar] 7.Rubtsova M.P., Vasilkova D.P., Malyavko A.N., Naraikina Y.V., Zvereva M.I., Dontsova O.A

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These have been pivotal in advancing noninvasive imaging techniques

Am J Med Genet 2002;107(2):1515