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Concurrently, it facilitated the phosphorylation of Smad2/3 downstream from TGF-, enhancing transduction within the TGF- signaling pathway, which subsequently promoted increased collagen content in these cells, thereby achieving significant antiphotoaging effects on the skin

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Mechanism of the Regulation of Organic Cation/carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines

[DOI] [PMC free article] [PubMed] [Google Scholar] [147].Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H, ASK1 is essential for JNK/SAPK activation by TRAF2