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Moreover, systemic comorbidities highly relevant to human periodontitis, such as diabetes, obesity, smoking, or agerelated immune senescence, are absent from most standard models despite their known effects on inflammatory networks, bone metabolism, and treatment outcomes [102]
This method allows the separation of molecules based on their size

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Early intervention and management of B12 deficiencies are key to maintaining healthy bodily function

Lephart ED, Naftolin F