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While disruptions in the Wnt/-catenin signaling pathway can significantly impact liver regeneration, the liver possesses compensatory mechanisms to overcome these challenges

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Necroptosis, regulated by receptor-interacting protein kinases (RIPK1/RIPK3) and mixed lineage kinase domain-like protein (MLKL), similarly contributes to immunogenic cell death and has been associated with improved responses to immunotherapy in melanoma (31, 32)

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Some studies also suggest it may promote nerve regeneration and protect against brain injury by modulating dopamine and serotonin pathways