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Cell Death Dis 4: e678, 2013

Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype

This section will go through what is currently known about how c-Myc promotes the different stages of metastasis, both within the tumor cells themselves and the tumor infiltrating cells, which include tumor infiltrating stromal cells, notably cancer-associated fibroblasts (CAFs), and tumor-infiltrating immune cells, comprising many types of innate immune cells, particularly tumor-associated macrophages (TAMs), as well as some types of adaptive immune cells [Fig

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and Harein, P.K