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Avoid alcohol, NSAIDs (e.g., aspirin, ibuprofen), or blood-thinning supplements 48 hours before treatment unless prescribed

In rod Igf-1r / mice, we found a significant decrease in the expression of fatty acid synthesis genes and decreased levels of some fatty acids

The participants compliance regarding capsule consumption was calculated as percentages of the number of duly taken capsules (as noted by participants) compared to the number of capsules provided in the protocol

proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36