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Binding of heme to its dedicated pocket causes closing of the lateral substrate gate and triggers the release of ADP + Pi caused by conformational changes of the nucleotide-binding site of CydC

By definition, drug repurposing is designed to redirect new or additional indications for three kinds of therapeutic molecules i.e., drugs approved for a particular indication, drugs that have already been well-characterized during their clinical development and accompanied by thorough post-market surveillance data, and drugs which have undergone some clinical development but were subsequently abandoned 23,24