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C-reactive protein and the insulin-like growth factor (IGF)-system in relation to risk of cardiovascular disease in different ethnic groups

Cancer 20 , 471480 (2020)

[52] In light of the disappointing results of clinical trials involving the administration of so-called direct antioxidants (e.g., vitamins C or E or beta carotene) [37], there is growing interest in strategies based on dietary or pharmacological upregulation of endogenous antioxidant defense genes, including those regulated by the master antioxidant and cell protective transcription factor nuclear factor (erythroid-derived 2)-like-2 (Nrf2), which regulates hundreds of antioxidant and cytoprotective proteins [20] by binding at antioxidant response element (ARE) consensus sequences in the promoter region of those genes

Diminution of arterial puls- es traversing the involved compartment is a late finding

Maternal Antioxidant Treatment Prevents the Adverse Effects of Prenatal Stress on the Offsprings Brain and Behavior. Neurobiology of Stress 13 (November)