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On the other hand, following ovulation, the increased activity of Cu/Zn-SOD during the early and mid-luteal phase supports corpus luteum function while its diminished activity during the regression phase is associated with luteolysis and cessation of corpus luteum function, ushering menstruation (127)

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These involve substantial volume loss, dermal thinning, and sometimes underlying fat pad changes that topical treatments alone cannot fully address

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