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Growing evidence indicates that immune activation and gut microbiota alterations may critically modulate both ASD pathophysiology and pharmacological treatment responses

2013;8(3, article e59005) doi: 10.1371/journal.pone.0059005

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While these clusters are predictive of disease activity, treatment requirements, complications, and mortality, it also points to autoantibodies as being a fundamental underlying mechanism of immune dysregulation and disease pathogenesis of SLE

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