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Problem or Solution: The Strange Story of Glucagon

In this weight management program subjects treated with liraglutide 3.0 mg experienced a dose-dependent weight loss ranging from 6.0 kg to 8.8 kg, whereas subjects treated with placebo (on diet and exercise alone) had a mean weight loss of 0.2 kg to 3.0 k (209)

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In short, liraglutide, GLP-1 receptor agonist, has a direct effect on atherosclerosis lesion formation via promoting pro-resolving M2 macrophages phenotype

Future directions include the design and synthesis of novel compounds that can mitigate these side effects while maintaining or enhancing efficacy