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FOXO4-DRI improves the testicular microenvironment in naturally aged mice FOXO4-DRI-treated aged testes showed decreased interstitial SA--gal activity (Figure 7A) as well as lower levels of senescence-associated proteins p53, p21, and p16 (Figure 7B7E)

This mechanism supports studies in cellular rejuvenation, energy production, and metabolic resilience

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2 The logic is elegant: after a carbohydrate-rich meal, most of the glycemic excursion is governed not by how fast the pancreas secretes insulin but by how fast glucose arrives in the small intestine to be absorbed