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In a study on smokers with alcohol and nicotine dependence, a satisfactory correlation coefficient (0.59) was reported for the relationship between FTND score and carbon monoxide level.(21) In contrast, a recent study involving light smokers showed that the correlation between FTND score and carbon monoxide level was very weak (0.19), as was the correlation (0.24) between FTND score and saliva cotinine.(32) In an investigation of the general population,(12) a better correlation between FTND score and saliva cotinine (0.45) was observed

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