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Dehydration increases heart rate because the heart must beat faster to maintain blood pressure with reduced blood volume
doi:10.1016/s0140-6736(21)01324-6 Ludvik B, Giorgino F, Jdar E, et al
A phase 2, 16-week, open-label study in 18 subjects ranging from 6 to 40 years of age results in a mean BMI reduction of 18% in those younger than 18 years, and 6% for those 18 years or older, accompanied by significant reduction of hunger scores (127)
Lancet 372, 12401250
They took blockbuster drugs for weight loss and diabetes
