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Approximately 86% of patients with T2DM are overweight or obese, and obesity is considered the greatest risk factor for T2DM (Daousi et al., 2006

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However, 15 to 60% of this can be lean mass, including muscle

In contrast, a peripheral injection of EX4 in rats reduced both basal locomotor activity and amphetamine-induced hyperactivity, which may be indicative of a reduced dopamine signal
