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Retatrutide is an investigational peptide studied for weight loss, glucose regulation, and metabolic health

doi: 10.1016/s0140-6736(19)31149-3

Further, in the FIGHT trial, which was the only trial sufficiently comprehensive to allow for the evaluation of hard outcomes, even though the HR was above 1 for the composite endpoint of hospital admission due to HF, the treatment effect did not reach statistical significance (HR [liraglutide vs

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Rapid dose escalation also increases the likelihood of nausea and early satiety, which is why PlexusDx and other providers recommend gradual titrationtypically starting at the lowest dose and advancing every 4 weeks based on tolerability