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For Employers and PBMs: No Automatic Change, But Significant Leverage For employers, this announcement does not automatically lower GLP-1 costsPBM contracts remain as written

Time-to-onset analysis revealed a median latency of 32 days (IQR 7122) for GLP-1 RA-related NAEs, with 45.28% occurring within 30 days of treatment initiation

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GLP-1 receptor agonists and dual GLP-1/GIP co-agonists can produce substantial weight loss, but caloric restriction and weight loss trigger adaptive thermogenesis ...

These medications have been extensively studied and have demonstrated benefits in diabetes management, weight reduction, cardiovascular risk reduction, and improvement in overall metabolic health for appropriately selected patients