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A #randomized controlled trial (n=800) demonstrated that the #GLP-1 receptor agonist, #semaglutide, administered for 72 weeks, led to: #Improved fibrosis in 37% of patients vs 22% with placebo #Resolution of steatohepatitis #Significant metabolic benefits including weight reduction and improved glycemic control #Based on these findings, in August 2025 the FDA approved #semaglutide for the treatment of MASH, marking a major milestone in hepatology and metabolic medicine
Long-term exposure to GLP-1R agonists resulted in C cell proliferation and the formation of C cell adenomas and (medullary thyroid) carcinomas in rodents (Elashoff et al., 2011
Distinct p53-mediated G1/S checkpoint responses in two NIH3T3 subclone cells following treatment with DNA-damaging agents
Oysters map perfectly to my lived experience (they trigger 1224 hours of flu-like symptoms ), so cutting them was a clear win
Medical weight loss should be supervised, personalized, and focused on long-term metabolic health, not just the number on the scale
