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Description
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding

can be inconsistent especially for weight loss medications

Yes, and in many cases, its encouraged

Janumet and Janumet XR can cause low blood sugar in people who also take certain other diabetes medications
Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice