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Moreover, ALT-801 is a balanced dual receptor agonist 19,20 with closely matched potencies at the GLP-1R and GCGR (39 pM and 42 pM, respectively 20 ), as distinguished from the dual agonists cotadutide 42 and BI456906 43 , which appear to be biased 5:1 and 7.5:1, respectively, toward GLP-1R activation

The drugs work by mimicking the hormone GLP-1 to slow digestion and reduce appetite, which can lead to significant weight loss

28 Ketones and electrolytes should be monitored hourly and every 2 hours, respectively, until blood ketones are 3.3 mEq/L

The advantage of lower doses is dramatically reduced side effect burden