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[DOI] [PubMed] [Google Scholar] 102.Butler P.C., Elashoff M., Elashoff R., Gale E.A

Overall, the use of the GLP-1 receptor agonist-SGLT-2 inhibitor combination was associated with a 30% lower risk of MACE (7.0 v 10.3 per 1000 person years

In the U.S., about 6% of adults currently use GLP-1s, and 12% have used them in the past (2024 data) (Mozafariun 2025)

For example, in the lungs, GLP-1s may reduce the inflammatory response, improve oxidative stress, regulate protease/anti-protease imbalance, improve airway mucus homeostasis, and reduce airway remodeling to provide benefit in patients with COPD

Mild gastrointestinal effects are among the most typical initial responses