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Tirzepatide dosing protocol Tirzepatide uses a longer, more gradual titration over 20 weeks to reach the maximum dose: Weeks 1-4: 2.5mg once weekly Weeks 5-8: 5mg once weekly Weeks 9-12: 7.5mg once weekly Weeks 13-16: 10mg once weekly Weeks 17-20: 12.5mg once weekly Week 21 onward: 15mg once weekly (maximum maintenance) Not everyone needs to reach 15mg